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The story is set in the devastated area of Kamata, Tokyo, in 1945 just after the end of the war. Horikita plays Shimomura Umeko, the youngest of three siblings whose father is a doctor at a university hospital. Compared to her outstanding sister Matsuko and brother Takeo, she lacks self-confidence, but an incident makes her determined to become a local doctor. However, her path is fraught with failures. --Tokyograph 

Uehara Jiro, in the sixth year at elementary school, is from a family of five; his parents who are both ex-extremists, his elder sister and a younger sister. Children look coldly at their father, Ichiro, who does not work but is quick at lashing out for anything illogical. One day, Jiro snaps at a junior high school student in the neighborhood who ridiculed his parents and causes a violent incident. Being tired of all the fuss made by the school and the response from the child welfare, the Uehara family moves to the island of Iriomotejima, father's hometown. However, the island is in the midst of a row over a development plan to build resort facilities, and the family is sucked into the mayhem. Ichiro and his wife Sakura are arrested, but they break loose. They are forced to live a life as fugitives, and are unable to live with their children. The children, however, understand that their parents do not want to succumb to the establishment and support them.

Tsukumo Ryusuke is a quirky, yet brilliant neuroscientist working for the National Research Institute of Police Science. Wielding a unique perspective and psychology, Tsukumo tackles the nation's most baffling crimes and scandals, going head-to-head with the most brilliant and twisted criminal minds. But his eccentricities and poor social timing can also aggravate people and circumstances, further complicating matters.