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Cheung Yat Kin (Kenneth Ma) recently graduated and started his practice in neurosurgery at Yan Oi Hospital. Kin is a goal-driven individual who took his work seriously and strictly followed the rules. Although his medical interns were afraid of his strict rules and high expectations, they respected his exceptional skills and experiences. Kin initially studied medicine because he was grateful to the doctor (Yu's father) who saved his younger brother Cheung Yat Hong’s (Nathan Ngai) life after a bad traffic accident. Kin took great care of his brother and worked hard to earn enough money to send his brother for an overseas's education. Because he was worried that his brother will be unable to take care of himself as his legs are paralyzed, Kin decided that his mother shall accompany his brother overseas. Thus Kin had to work doubly hard to enough money to support both of them. Kin’s incredible work ethic enabled him to work hard and save enough money to support his brother financially. For that reason, Kin did not consider being committed into a relationship until he met Fan Chi Yu (Tavia Yeung). Yu, a reputable doctor, worked on several projects with Kin and found herself falling in love with him. However, when she found out that her long lost sister, Fan Mei Suet (Mandy Wong), also liked Kin, she decided to give up on pursuing him. Subsequently, Kin realized that he also had feelings for Yu when she stopped talking to him and confessed his love to her. Shortly after Kin and Yu started their relationship, Hong got into accident and tragically died. Kin’s grief over his younger brother’s tragic death greatly influenced his attitude towards his interns, especially Yeung Pui Chung (Him Law), who Kin had always considered him as a younger brother. To make matters worse, Kin suddenly finds out that Yu suffers from tumor in her spine and that it may become life-threatening. Yu actively searched for treatment and her persistent spirit motivated Kin to get back on his feet to support her. Unfortunately, Yu’s condition worsened, and she took the risk of undergoing a dangerous surgery. As a doctor and Yu’s boyfriend, Kin and Yu's father took on the challenge to do the surgery on her. After enduring the hardships together, Kin and Yu’s feelings grew deeper and got happily married.

When Nina wins free airline tickets, she leaves her dingy apartment and part-time factory job in Yamato City, Japan for Singapore with her friend Su.