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Based on a best-selling novel written by Xin Yiwu, the story follows 18-year-old Zheng Wei (Yang Zishan) who enrols in university to remain close to her childhood crush, Lin Jing (Han Geng). When Lin moves abroad to pursue his education, life loses its lustre for Zheng until she meets the dashing but aloof Chen Xiaozheng (Mark Chao), who also leaves her to study abroad. Years later, when Zheng is a successful young professional type, the two heartthrobs resurface only to upset her comfortable reality once more.

Jae-hyuk (Kim Myung-min) is a former professor with a doctorate in biochemistry who is currently working as a pharmaceutical sales representative after losing his life savings and his job due to a bad investment he made in the stock market from advice he received from his younger brother. When a series of dead bodies are found floating in the Han River, the public is shocked to discover that the deaths are related to a fatal outbreak of virus-infected mutant parasitic horsehair worms, called Yeongasi, that can control the human brain. Those infected show symptoms of increased hunger without appropriate weight gain and excessive thirst when the worms are mature and ready to reproduce. Hence, they jump into the river to allow the worms to come out of the body. While the authorities work to find a cure, Jae-hyuk and his brother Jae-pil (Kim Dong-wan), a detective agonized with guilt for squandering Jae-hyuk's money in the stock market, struggle to save Jae-hyuk's family when they also exhibit similar symptoms. 

When tragedy happens, no one is outsider. A public slashing incident connects a group of young lost souls in Taipei city.