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Set in the 70's era of Mumbai and raised in the impoverished dagdi chawl's, mill worker Arun Gulab Gawli rises to the position of a dreaded don, a politician and ultimately becomes the chief adversary of the renowned Dawood Ibrahim.

Panat is the oldest son of Preemsuda who works as a secretary for Piraya's father, Peeradate, a government official. Panat and Piraya are lovers who decided to get married quietly in Spain. After their honeymoon, they both returned home to find that Pasin, Panat's younger brother, had fallen in love and was staying with Pasika, Piraya's younger sister. However, Panat carries the burden of a deep dark secret that would eventually make Pasin and Pasika's romance impossible and break down his own relationship with Piraya. After the secret is revealed, things escalate. The girls' mother falls ill and loses her sanity. Piraya ends her relationship with Panat, so he and his brother go study abroad. Pasika runs away from home and Piraya is left alone to take care of her mother and the family's company. Years later, Panat returns as a doctor. Even though he is still in love with his ex wife, he starts dating and gets engaged with Wasitha. On the day of his engagement, Piraya shows up and announces that he is her husband, since they were married in Spain, years earlier. Panat is happy to be with Piraya, but he does not realize that she is only planning on revenge towards him, his mother and her father.

Dr. Jekyll and Mr. Guide is a new show exploring diverse variants that determine the quality of life: healthcare, finance, vitality, etc. The celebrity guides viewers to explore various issues and topics with help from experts in those fields.