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In Seoul in the 1970s, a woman who almost died renamed herself Sam Saeng, becoming a herbal doctor and succeeding in her troubles.

By chance, Ma Jia, a doctor from the First Affiliated Hospital of Jiangnan University, joined the 25th Chinese medical team to aid Sanna and went to Africa. Faced with completely different environments and huge cultural differences between China and Africa Ma Jia experienced both persistence and giving up. Adjusting and correcting his mentality, to gradually understand what it means to be a Chinese foreign aid doctor in practice. During the two years of foreign aid, during the physical and mental training, and under the scrutiny of emotions and low spirits, Ma Jia and his partners in the foreign aid medical team were stationed in "Maile Village", experiencing happiness, touching reunions, separations, and exciting experiences.

"Kaiki Renai Sakusen" follows three women and depicts their persona lives, work lives and their fight against a monster. Natsumi (Kumiko Aso) is 36-years-old. She dreamed of becoming a cafe owner and saved money to achieve her dream, but she was swindled out of her money. She now works at the cafe where she dreamed of becoming the owner. Akiko (Maki Sakai) is 39-years-old. She works as a music teacher and awaits for the perfect man. Fuyu (Tamaki Ogawa) is 38-years-old. She thinks of herself as an actress.