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Luo Ran has been investigating the death of his wife with his best friend Ning Yu. They end up getting onto a train headed for C City in order to chase female suspect Jiang Xue. The train suddenly derails mid-journey, and the hundred or so survivors find themselves transported to a ruined city with no living soul in sight, cut off from the rest of the world. The city is filled with dangers on all sides and supplies are dwindling. The survivors start dying off or disappearing one by one—a brutal game of survival begins.