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Soma Ito is a high school student in Hirosaki, Aomori Prefecture. She has a talent for playing Tsugaru-shamisen. The music is native to Aomori Prefecture and involves the traditional folk instrument Tsugaru-shamisen, which is a plucked three-string instrument. Ito learned to play Tsugaru-shamisen from her now-deceased mother. Due to her strong Tsugaru dialect and her shy personality, she has a hard time playing in public and also experiences difficulty in social settings. She doesn't have any friends. To change herself, Ito begins a part-time job at a maid cafe. Her father Koichi watches anxiously over her, while she works her new job. By meeting various people, Ito begins to grow as a person.

Nasuda Ayumi is a young travel nurse who gives a bad first impression. In fact, he had been an excellent nurse practitioner in the US. He has the qualifications to carry out certain medical procedures and assist doctors in surgeries. However, some circumstances trigger his return to Japan where nurse practitioners are relatively unknown and nurses are still expected to do what doctors order. Ayumi ends up working at Amano General Medical Centre where he encounters a mysterious, legendary nurse Kuki Shizuka who will become his partner. Shizuka cleans “quietly” just like his name suggests and gets mistaken for a cleaner by the hospital staff including Ayumi. But he is actually a super nurse with boggling skills. Although Shizuka does not defy doctors and is too soft, when it comes to the crunch, he would boldly take decisive action with scathing words. He is quite a “liar” and has a huge secret. With their respective skills and philosophies, Ayumi and Shizuka are different types of unsung nurses who repulse each other but also collaborate to slowly bring about changes in not only the patients but also the healthcare professionals around them.