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"Iryu Sosa" depicts the work of a group of detectives who solve murder cases by looking for clues in the articles left by victims.

Ruan Liu Zheng returns to her hometown after seven years, and becomes a neurosurgeon at Bei Ya Hospital. However, she did not expect to meet her ex-husband, Ning Zhi Qian, who is the most experienced neurosurgeon at Bei Ya Hospital. Ning Zhi Qian volunteers to be Ruan Liu Zheng's mentor, in order to make up for the hurt he caused her. Ruan Liu Zheng is no longer the weak and timid girl, and shows resolute and determination in both her work and relationship. During work, Ruan Liu Zheng clashes with Ning Zhi Qian, but also works alongside him to save lives. When they were in Africa to execute medical relieve efforts, Ning Zhi Qian was injured while saving a patient. Ruan Liu Zheng does not leave his side, and fought hard to save him from the brink of death. Over time, the two gained a new understanding of life, and begin a new relationship.

Kae Horii (Erika Sawajiri) moves into her new flat in an undisclosed area of Kyoto. While unpacking her belongings, she discovers a hidden compartment behind a inconspicuous mirror. In that compartment, Kae finds a notebook, that turns out to be a diary belonging to the previous tenant. Later that evening Kae starts to read the diary. The writer of the diary is Ibuki Mano (Yuko Takeuchi), a young lady about to embark on her first year as an elementary school teacher. Ibuki is also in love with a man named Takashi, who may or may not hold similar feelings for Ibuki. The diary immediately resonates with Kae, as she plans to become an elementary school teacher herself. Ibuki’s experiences also works as an inspirational instructional guide for Kae’s own personal life. Kae is also in love with an aloof illustrator/artist (Yusuke Iseya), who may or may not hold similar feelings for Kae.

Yoo Joo was born and lived in Gwangju for 30 years. Her original dream was to be a food photographer, and now she works as a photographer and marketing agent for an advertising company. As she entered her third year, her personality has changed a lot. In the past, she used to be arrogant and stubborn, but now she doesn't even put her mouth on, and only chooses good words to listen to clients.