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The story revolves around four good friends who slowly discover their feelings for each other, and how their relationship changes from friends to lovers.

Explorers of the Human Body's aim was to answer curious questions about the human body, where the Super Junior members perform the answers by doing experiments with their own bodies. It was also the first and currently the only variety show that included every member of Super Junior as regulars.

The drama follows the story of a man, Choi Suk Bong, who believes that he is actually the son of a rich father and heir to a chaebol group. He meets Lee Shin Mi, who is actually a chaebol heir but acts nothing like one, with her scrimping and frugal ways. Although they get off to a rocky start, with her help, he struggles towards his goal of attaining wealth.